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201 Cypress Ave | Development Opportunity | South San Francisco

$2,700,000

201 Cypress Ave, South San Francisco, CA 94080

Active
Last Updated: 10/06/2025

2,750 sqft

Building Size

0.2311 acres

Lot Area

Details:
Building Size:    2,750 sqft
Lot Area:    0.2311 acres
Units:    1
Highlights:
  • Active-Street Vision Encourages Ground-Floor Retail/Service Uses
  • Prime Downtown SSF
  • Eligible pathways for State/Local Density Bonus with affordability
  • Generous envelope: ~85 ft height potential; high FAR; ~100–180 units/acre
Description:

201 Cypress Avenue is a 10,067 SF automotive and redevelopment site in South San Francisco’s Downtown and Caltrain Station Area. The property consists of a structure leased to an auto body shop and a yard leased to taxi cab users, each on a month-to-month basis, offering a buyer immediate flexibility for redevelopment or repositioning.

The site is zoned Downtown Transit Core (DTC), which supports transit-oriented, high-density mixed-use development. Allowed uses include residential, office, life science and R&D, service, and retail.

The district provides generous height and floor area ratio allowances and no minimum residential parking, with city maximums and potential reductions available. Environmental remediation has been completed. Underground storage tanks were removed and a Phase III investigation was closed, reducing redevelopment risk and helping streamline entitlement and financing.

The property has excellent access to Caltrain, US 101, I-280, and San Francisco International Airport. It is surrounded by South San Francisco’s growing biotech, logistics, and commercial ecosystem, making it an ideal location for new mixed-use or residential development.

The city of South San Francisco (SoSF) is internationally recognized as the Biotech Capital of the World. Located immediately south of the San Francisco border, its commercial landscape is dominated by a dense cluster of global life sciences and pharmaceutical companies, including Genentech. This area is known for its modern research parks, robust infrastructure, and strategic positioning near SFO International Airport and major transportation corridors, making it a crucial innovation and employment hub for the entire Bay Area.

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